Merlin Antikörper

Produktnummer ABIN966568

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Merlin in IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte. Es wurde in 3+ Publikationen zitiert.

Kurzübersicht für Merlin Antikörper (ABIN966568)

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Merlin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-Merlin Antikörper

Spezifität: Merlin (Ab-518) antibody detects endogenous levels of total Merlin protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human Merlin around the phosphorylation site of serine 518 (R-L-SP-M-E).

Anwendungsinformationen

Applikationshinweise: WB: 1:500~1:1000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-Merlin Antikörper (ABIN966568)

Xiao, Gallagher, Shetler, Skele, Altomare, Pestell, Jhanwar, Testa: "The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression." in: Molecular and cellular biology, Vol. 25, Issue 6, pp. 2384-94, (2005) (PubMed).

Ratner, Bryan, Weber, Nguyen, Barnes, Pitt, Gelber, Cheung, Prince: "Cystic fibrosis pathogens activate Ca2+-dependent mitogen-activated protein kinase signaling pathways in airway epithelial cells." in: The Journal of biological chemistry, Vol. 276, Issue 22, pp. 19267-75, (2001) (PubMed).

Böhni, Hemmi, Aguet: "Signaling steps involving the cytoplasmic domain of the interferon-gamma receptor alpha-subunit are not species-specific." in: The Journal of biological chemistry, Vol. 269, Issue 20, pp. 14541-5, (1994) (PubMed).

Details zu Merlin

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Andere Bezeichnung: Merlin

Pathways: Cell-Cell Junction Organization