Lipase A Antikörper

Produktnummer ABIN966473

Produktdetails anti-Lipase A Antikörper

Target: Lipase A (LIPA) (Lipase A, Lysosomal Acid, Cholesterol Esterase (LIPA))

Reaktivität: Human

Wirt: Bitte anfragen

Klonalität: Monoklonal

Konjugat: Dieser Lipase A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: Ni-NTA purified truncated recombinant LAL expressed in E. Coli strain BL21 (DE3)

Aufreinigung: Antibodies are purified by protein A affinity chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot: Dilution 1: 200- 1: 1,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: -20 °C

Referenzen für anti-Lipase A Antikörper (ABIN966473)

Drebber, Andersen, Kasper, Lohse, Stolte, Dienes: "Severe chronic diarrhea and weight loss in cholesteryl ester storage disease: a case report." in: World journal of gastroenterology : WJG, Vol. 11, Issue 15, pp. 2364-6, (2005) (PubMed).

Boldrini, Devito, Biselli, Filocamo, Bosman: "Wolman disease and cholesteryl ester storage disease diagnosed by histological and ultrastructural examination of intestinal and liver biopsy." in: Pathology, research and practice, Vol. 200, Issue 3, pp. 231-40, (2004) (PubMed).

Details zu Lipase A

Target: Lipase A (LIPA) (Lipase A, Lysosomal Acid, Cholesterol Esterase (LIPA))

Andere Bezeichnung: LAL (LIPA Produkte)

Synonyme: cesd antikoerper, lal antikoerper, LIPA antikoerper, CESD antikoerper, LAL antikoerper, Chole antikoerper, Chole2 antikoerper, Lip1 antikoerper, AA960673 antikoerper, Lal antikoerper, Lip-1 antikoerper, lipase A, lysosomal acid type antikoerper, lipase A, lysosomal acid, cholesterol esterase antikoerper, lipase A, lysosomal acid, cholesterol esterase L homeolog antikoerper, lysosomal acid lipase A antikoerper, LIPA antikoerper, lipa antikoerper, lipa.L antikoerper, Lipa antikoerper

Hintergrund: Lysosomal acid lipase (LAL), with 378-amino acid protein( 43-54 kDa), functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides which are taken up by receptor-mediated endocytosis. An inherited deficiency or low activity of human lysosomal acid lipase results in the intralysosomal storage of the respective lipid substrates. So it is also responsible for the rare conditions of Wolman disease and cholesteryl ester storage disease (CESD). As the enzyme is synthesized by all nucleated cells, lipid-laden cells are found in all organs, particularly in liver, spleen, the adrenal and the hemopoietic system, and in the intestine as well as in the lymph nodes, lungs, testes, and ovaries.