KSHVORF45 Antikörper
Reaktivität: Human Herpesvirus 8 (HHV-8)
ELISA, WB
Monoclonal
unconjugated
(3 Referenzen)-
- Target
- KSHVORF45
- Reaktivität
- Human Herpesvirus 8 (HHV-8)
- Wirt
- Bitte anfragen
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Klonalität
- Monoklonal
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Konjugat
- Unkonjugiert
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Applikation
- ELISA, Western Blotting (WB)
- Spezifität
- Ni-NTA purified recombinant human KSHV ORF45 expressed in E. Coli strain BL21 (DE3).
- Aufreinigung
- Crude ascites.
- Isotyp
- IgG1
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anti-KSHVORF45 antibody
Reaktivität: Human Herpesvirus 8 (HHV-8) ELISA, WB, IHC Wirt: Maus Monoclonal 2D4A5 unconjugated
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- Applikationshinweise
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Dilution: Western Blot: 1:500-1,000
ELISA: Determining optimal working dilutions by titration test. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Lagerung
- -20 °C
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: "The ORF45 protein of Kaposi's sarcoma-associated herpesvirus is associated with purified virions." in: Journal of virology, Vol. 77, Issue 7, pp. 4221-30, (2003) (PubMed).
: "A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 8, pp. 5573-8, (2002) (PubMed).
: "Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma." in: Science (New York, N.Y.), Vol. 266, Issue 5192, pp. 1865-9, (1995) (PubMed).
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: "The ORF45 protein of Kaposi's sarcoma-associated herpesvirus is associated with purified virions." in: Journal of virology, Vol. 77, Issue 7, pp. 4221-30, (2003) (PubMed).
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- Target
- KSHVORF45
- Substanzklasse
- Viral Protein
- Hintergrund
- Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediateearly gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions
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