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DISC1 Antikörper (C-Term)

DISC1 Reaktivität: Human IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN965998
  • Target Alle DISC1 Antikörper anzeigen
    DISC1 (Disrupted in Schizophrenia 1 (DISC1))
    Bindungsspezifität
    • 15
    • 14
    • 7
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 71
    • 25
    • 14
    • 1
    Human
    Wirt
    • 70
    • 4
    • 1
    • 1
    Kaninchen
    Klonalität
    • 72
    • 6
    Polyklonal
    Konjugat
    • 43
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DISC1 Antikörper ist unkonjugiert
    Applikation
    • 48
    • 31
    • 26
    • 14
    • 14
    • 11
    • 11
    • 8
    • 6
    • 5
    • 5
    • 3
    • 1
    Immunohistochemistry (IHC)
    Aufreinigung
    Purified by antigen-specific affinity chromatography.
    Immunogen
    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human DISC1(Disrupted in schizophrenia 1 protein)
    Top Product
    Discover our top product DISC1 Primärantikörper
  • Applikationshinweise
    ELISA, Western blotting: 1µg/ml for 2hrs.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    This antibody is stored in PBS, 50% glycerol
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Taylor, Devon, Millar, Porteous: "Evolutionary constraints on the Disrupted in Schizophrenia locus." in: Genomics, Vol. 81, Issue 1, pp. 67-77, (2003) (PubMed).

    Morris, Kandpal, Ma, Austin: "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation." in: Human molecular genetics, Vol. 12, Issue 13, pp. 1591-608, (2003) (PubMed).

    Ozeki, Tomoda, Kleiderlein, Kamiya, Bord, Fujii, Okawa, Yamada, Hatten, Snyder, Ross, Sawa: "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 1, pp. 289-94, (2003) (PubMed).

    Millar, Wilson-Annan, Anderson, Christie, Taylor, Semple, Devon, St Clair, Muir, Blackwood, Porteous: "Disruption of two novel genes by a translocation co-segregating with schizophrenia." in: Human molecular genetics, Vol. 9, Issue 9, pp. 1415-23, (2000) (PubMed).

    Seki, Ohira, Nagase, Ishikawa, Miyajima, Nakajima, Nomura, Ohara: "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 4, Issue 5, pp. 345-9, (1998) (PubMed).

  • Target
    DISC1 (Disrupted in Schizophrenia 1 (DISC1))
    Andere Bezeichnung
    DISC1 (Disrupted in schizophrenia 1 protein) (DISC1 Produkte)
    Synonyme
    DISC1 antikoerper, C1orf136 antikoerper, SCZD9 antikoerper, disrupted in schizophrenia 1 antikoerper, disrupted in schizophrenia 1 protein antikoerper, disc1 antikoerper, DISC1 antikoerper, LOC100580606 antikoerper, Disc1 antikoerper
    Hintergrund
    DISC1 (Disrupted in schizophrenia 1 protein) is a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. DISC1 is involved in neurite outgrowth and cortical development through its interaction with other proteins. DISC1 interacts with tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1 and TRAF3IP1. The interaction with microtubules may be mediated in part by TRAF3IP1. A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1,11)(q42.1,q14.3). The truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 and NDEL1.
    Pathways
    Regulation of Cell Size
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