SIAH1/2 Antikörper (AA 201-300) (AbBy Fluor® 488)

Produktnummer ABIN915201

Der AbBy Fluor® 488-konjugierte Kaninchen Polyklonal anti-SIAH1/2 Antikörper (ABIN915201) detektiert spezifisch SIAH1/2 in WB, IF (cc) und IF (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für SIAH1/2 Antikörper (AA 201-300) (AbBy Fluor® 488) (ABIN915201)

Target: SIAH1/2 (Seven in Absentia Homolog 1/2 (SIAH1/2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIAH1/2 Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-SIAH1/2 Antikörper (AbBy Fluor® 488)

Bindungsspezifität: AA 201-300

Verwendungszweck: SIAH2 Polyclonal Antibody, AbBy Fluor-488 Conjugated

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SIAH2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:300-5000), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu SIAH1/2

Target: SIAH1/2 (Seven in Absentia Homolog 1/2 (SIAH1/2))

Andere Bezeichnung: SIAH1/2

Hintergrund:

Synonyms: Seven in Absentia Homolog 2, Ubiquitin Ligase Siah2, SIAH2_HUMAN, E3 ubiquitin-protein ligase SIAH2, Seven in absentia homolog 2, Siah-2, hSiah2, Siah-1, Siah-1a, E3 ubiquitin-protein ligase SIAH1, Seven in absentia homolog 1.

Background: Siah2 is a E3 Ubiquitin ligase protein that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targets. Siah2 triggers the ubiquitin-mediated degradation of many proteins, including transcription regulators (e.g. POU2AF1, PML, NCOR1), cell surface receptors (e.g. DCC), antiapoptotic proteins (e.g. BAG1), and proteins involved in synaptic vesicle function in neurons (e.g. SYP). Siah2 has some overlapping function with SIAH1 but is able to trigger the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not.

Gen-ID: 6478

UniProt: O43255, Q8IUQ4