Ataxin 1 Antikörper

Produktnummer ABIN865485

Der Maus Monoklonal anti-Ataxin 1 Antikörper (Klon 2F5) (ABIN865485) detektiert spezifisch Ataxin 1 in WB, IHC, ELISA, IF und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Ataxin 1 Antikörper (ABIN865485)

Target: Ataxin 1 (ATXN1)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Ataxin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: 2F5

Produktdetails anti-Ataxin 1 Antikörper

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human ATXN1 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF: 1/200 - 1/1000, FC: 1/200-1/400 ELISA: Propose dilution 1/10000. Figure 3: Immunofluorescence

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100g/100l

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Details zu Ataxin 1

Target: Ataxin 1 (ATXN1)

Andere Bezeichnung: ATXN1

Hintergrund: The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. Synonyms: ATX1, SCA1, D6S504E, ATXN1

Molekulargewicht: 87kDa

Gen-ID: 6310

Pathways: Synaptic Membrane