SLC29A4 Antikörper (AA 401-500)

Produktnummer ABIN754948

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SLC29A4 in WB, ELISA, FACS, IF (cc), IF (p), IHC (p) und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Human und Ratte.Es wurde in 1 Publikation zitiert.

Kurzübersicht für SLC29A4 Antikörper (AA 401-500) (ABIN754948)

Target: SLC29A4 (Solute Carrier Family 29 (Nucleoside Transporters), Member 4 (SLC29A4))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC29A4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-SLC29A4 Antikörper

Bindungsspezifität: AA 401-500

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Dog,Cow,Pig,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SLC29A4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-SLC29A4 Antikörper (ABIN754948)

Zechner, Bürtin, Albert, Zhang, Kumstel, Schönrogge, Graffunder, Shih, Müller, Radecke, Jaster, Vollmar: "Intratumoral heterogeneity of the therapeutical response to gemcitabine and metformin." in: Oncotarget, Vol. 7, Issue 35, pp. 56395-56407, (2018) (PubMed).

Details zu SLC29A4

Target: SLC29A4 (Solute Carrier Family 29 (Nucleoside Transporters), Member 4 (SLC29A4))

Andere Bezeichnung: SLC29A4

Hintergrund:

Synonyms: ENT4, PMAT, Equilibrative nucleoside transporter 4, hENT4, Plasma membrane monoamine transporter, Solute carrier family 29 member 4, SLC29A4, PSEC0113

Background: Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH , with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia.

Gen-ID: 222962

UniProt: Q7RTT9