GRIN2B Antikörper (pTyr1070) (PE-Cy7)

Produktnummer ABIN744366

Der PE-Cy7-konjugierte Kaninchen Polyklonal anti-GRIN2B Antikörper (ABIN744366) detektiert spezifisch GRIN2B in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Maus, Hund, Rind (Kuh) und Huhn.

Kurzübersicht für GRIN2B Antikörper (pTyr1070) (PE-Cy7) (ABIN744366)

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRIN2B Antikörper ist konjugiert mit PE-Cy7

Applikation: Western Blotting (WB)

Produktdetails anti-GRIN2B Antikörper (PE-Cy7)

Bindungsspezifität: pTyr1070

Spezifität: This phosphorylated site is homologous to that of Tyr1070 in Mouse and Rat.

Homologie: Human,Mouse,Rat,Dog,Cow,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human NMDAR2B around the phosphorylation site of Tyr1070

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu GRIN2B

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Andere Bezeichnung: NMDAR2B

Hintergrund:

Synonyms: MRD6, NR2B, hNR3, GluN2B, NMDAR2B, Glutamate receptor ionotropic, NMDA 2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NR3, GRIN2B

Background: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).

Molekulargewicht: 163kDa

Gen-ID: 2904

UniProt: Q13224

Pathways: Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity