Apelin (APLN) Antikörper (Biotin)

Antigen: Apelin (APLN)

Synonyme: Apel, 6030430G11Rik, XNPEP2, APLN, Xapelin, xnpep2, preproapelin

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus)

Konjugat: Biotin

Applikation: Western Blot (WB), ELISA, Immunpräzipitation (IP), Immunhistochemie (Paraffinschnitte) (IHC (p)), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)), Durchflusszytometrie (FACS), Immunfluoreszenz (IF)

Produktnummer: ABIN740087

Produktbeschreibung

Weitere Bezeichnung: Apelin

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human Apelin C-terminus

Format: Lyophilized

Wiederherstellung: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotyp: IgG

Beschreibung: Synonym: APLN, Apel, AGTRL1 ligand, APEL, APJ endogenous ligand, XNPEP2.

Molekulargewicht: 10kDa

Kommentare:

Apelin is a neuropeptide expressed in the supraoptic and paraventricular nuclei and is an endogenous ligand for APJ

a G protein-coupled orphan receptor which is an alternative coreceptor with CD4 for HIV-1. Apelin and APJ are ubiquitously expressed in peripheral tissues

with highest levels reported for heart and lungs

as well several regions within the central nervous system. The actions of apelin remain largely unknown: Apelin inhibits HIV-1 entry in cells coexpressing CD4 and APJ

the oral intake of Apelin in colostrum and breast milk could have a role in the modulation of the immune responses in neonates

more recent studies have also indicated a role for Apelin in the central control of body fluid homeostasis

by influencing AVP release and drinking behavior. In the cardiovascular system several actions of Apelin have been described

including endothelium-dependent vasodilatation

vasoconstriction through direct action on smooth muscle and positive inotropism.

Anwendungen

Applikationshinweise: WB (1:100-500), ELISA (1:500-1000), IP (1:20-100), IHC-P (1:100-500), IHC-F (1:100-500), Flow-Cyt (1:20-100), IF (1:50-200)

Konzentration: 1mg/1ml

Reinigung: Antibodies are purified by protein A and peptide affinity chromatography.

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Lagerung: Ship at room temperature. Store at -20°C

Forschungsgebiet: Kardiovaskuläres System, Kontraktilität

Beschränkungen: Nur für Forschungszwecke einsetzbar