HPV16 E7 Antikörper

Produktnummer ABIN730648

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch HPV16 E7 in WB, IF (p) und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human Papillomavirus 16 (HPV-16).

Kurzübersicht für HPV16 E7 Antikörper (ABIN730648)

Target: HPV16 E7 (HPV-16 E7) (Human Papilloma Virus 16 E7 (HPV-16 E7))

Reaktivität: Human Papillomavirus 16 (HPV-16)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HPV16 E7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-HPV16 E7 Antikörper

Kreuzreaktivität: Virus

Kreuzreaktivität (Details): HPV16

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from middle of HPV16-E7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB (1:100-500),IHC-P (1:100-500),IF (p) (1:100-500)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu HPV16 E7

Target: HPV16 E7 (HPV-16 E7) (Human Papilloma Virus 16 E7 (HPV-16 E7))

Andere Bezeichnung: HPV16 E7

Substanzklasse: Viral Protein

Hintergrund:

Synonyms: E7, Human Papilloma Virus, Human papillomavirus type 16 E7, Human papillomavirus type 16 E7, Protein E7, Human Papillomavirus 16 E7, HPV16 E7, E7 protein HPV16, VE7_HPV16.

Background: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90 % of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.

Molekulargewicht: 11kDa

Gen-ID: 1489079