KCNN4 Antikörper (AA 325-427)

Produktnummer ABIN719786

Es sind 2+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-KCNN4 Antikörper wird verwendet zum Nachweis von KCNN4 in Proben von Human und Ratte. Er wurde validiert für WB, ELISA, IHC (p), IF (cc), IF (p) und IHC (fro).

Kurzübersicht für KCNN4 Antikörper (AA 325-427) (ABIN719786)

Target: KCNN4 (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNN4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-KCNN4 Antikörper

Bindungsspezifität: AA 325-427

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KCNN4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-KCNN4 Antikörper (ABIN719786)

Lively, Lam, Wong, Schlichter: "Comparing Effects of Transforming Growth Factor β1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels." in: Frontiers in cellular neuroscience, Vol. 12, pp. 115, (2018) (PubMed).

Zhang, Yang, Yin, Yi, Shen, Zhao, Zhu, Liu: "Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells." in: PLoS ONE, Vol. 11, Issue 4, pp. e0154471, (2016) (PubMed).

Details zu KCNN4

Target: KCNN4 (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4))

Andere Bezeichnung: KCNN4

Hintergrund:

Synonyms: IK1, SK4, KCA4, hSK4, IKCA1, hKCa4, KCa3.1, hIKCa1, Intermediate conductance calcium-activated potassium channel protein 4, SKCa 4, SKCa4, Putative Gardos channel, KCNN4

Background: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.

Gen-ID: 3783

UniProt: O15554