SLIT and NTRK-Like Family, Member 1 (SLITRK1) Antikörper (HRP)

Antigen: SLIT and NTRK-Like Family, Member 1 (SLITRK1)

Synonyme: 3200001I04Rik, TTM, LRRC12, FLJ54428, KIAA0918, KIAA1910, RP11-395N17.1, DKFZp459G0529

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus)

Konjugat: HRP

Applikation: Western Blot (WB), ELISA

Produktnummer: ABIN715565

Produktbeschreibung

Weitere Bezeichnung: Slitrk1

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human Slitrk1

Format: Lyophilized

Wiederherstellung: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotyp: IgG

Beschreibung: Synonym: SLITRK 1, KIAA0918, KIAA1910, Leucine rich repeat containing protein 12, SLITRK 1, LRRC1, SLIT and NTRK like family, member 1.

Molekulargewicht: 78-88kDa

Kommentare:

Slitrk1 is a member of a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit

a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues

but varies within the family. For example

Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites

while expression of the other Slitrk proteins inhibited neurite outgrowth

suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette’s Syndrome

it is thought to play only a minor role if at all.

Anwendungen

Applikationshinweise: WB (1:200-1000), ELISA (1:500-1000)

Konzentration: 1mg/1ml

Reinigung: Antibodies are purified by protein A and peptide affinity chromatography.

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Lagerung: Ship at room temperature. Store at -20°C

Forschungsgebiet: Neurologie, Neurogenese

Beschränkungen: Nur für Forschungszwecke einsetzbar