Hemagglutinin Antikörper

Produktnummer ABIN676553

Der Kaninchen Polyklonal anti-Hemagglutinin Antikörper wird verwendet zum Nachweis von Hemagglutinin in Proben von Influenza A Virus H1N1. Er wurde validiert für ELISA, WB, IF (p), IF (cc), IHC (p) und IHC (fro).

Kurzübersicht für Hemagglutinin Antikörper (ABIN676553)

Target: Hemagglutinin (HA)

Reaktivität: Influenza A Virus H1N1

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Hemagglutinin Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-Hemagglutinin Antikörper

Virus Strain: A/California/04/2009

Kreuzreaktivität: Virus

Kreuzreaktivität (Details): Influenza A virus H1N1 (strain swl A/California/04/2009 H1N1)

Produktmerkmale: Antibody is specific for: Influenza A virus H1N1 (strain swl A/California/04/2009 H1N1)

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from Influenza A Virus Hemagglutinin (strain swl A/California/04/2009 H1N1)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu Hemagglutinin

Target: Hemagglutinin (HA)

Substanzklasse: Influenza Protein

Hintergrund:

Synonyms: HA, HA2, Hemagglutinin, Influenza A Virus (strain swl A/California/04/2009 H1N1)

Background: Influenza A virus is a major public health threat. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals, however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Influenza A Virus (strain swl A/California/04/2009 H1N1)

UniProt: C3W5S1