5 lipoxygenase/ALOX5 Antikörper

Antigen: 5 lipoxygenase/ALOX5

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus), Rind (Kuh), Pferd, Schwein, Hund, Kaninchen

Applikation: Western Blot (WB), ELISA, Immunpräzipitation (IP), Immunhistochemie (Paraffinschnitte) (IHC (p)), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)), Durchflusszytometrie (FACS), Immunfluoreszenz (IF)

Produktnummer: ABIN669651

Produktbeschreibung

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human 5 Lipoxygenase

Format: Lyophilized

Wiederherstellung: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Synonym: 5-lipoxygenase, 5-LOX, 5 LO, 5LPG, ALOX 5, ALOX5, Arachidonate 5 lipoxygenase, Arachidonic acid 5 lipoxygenase, Leukotriene A4 synthase, LOG 5, LOG5, MGC163204.

Molekulargewicht: 78kDa

Kommentare:

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein

which is expressed specifically in bone marrow-derived cells

catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8

11

14-cis-eicosatetraenoic acid

and further to the allylic epoxide 5(S)-trans-7

9-trans-11

14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed

but their full-length nature has not been determined.

Anwendungen

Applikationshinweise: WB (1:100-500), ELISA (1:500-1000), IP (1:20-100), IHC-P (1:100-500), IHC-F (1:100-500), Flow-Cyt (1:20-100), IF (1:50-200)

Konzentration: 1mg/1ml

Reinigung: affinity purified by Protein A

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Lagerung: Ship at room temperature. Store at -20°C

Beschränkungen: Nur für Forschungszwecke einsetzbar