BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 9-37), (N-Term) Antikörper

Produktnummer ABIN652513

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch BRISC and BRCA1 A Complex Member 1 in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 9-37), (N-Term) Antikörper (ABIN652513)

Target: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB20467

Produktdetails

Bindungsspezifität: AA 9-37, N-Term

Homologie: B, Zf

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HSPC142 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-37 amino acids from the N-terminal region of human HSPC142.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Antigendetails

Target: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Andere Bezeichnung: HSPC142

Hintergrund: HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component

Molekulargewicht: 36560

Gen-ID: 29086

NCBI Accession: NP_001028721, NP_054892

UniProt: Q9NWV8

Pathways: Positive Regulation of Response to DNA Damage Stimulus