Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13) Antikörper

Antigen: Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13)

Synonyme: APRIL, CD256, TALL2, TRDL-1, ligand, UNQ383/PRO715, TRDL1, Tnfsf12, MGC106105, 2310026N09Rik, SLAN, ANP32B, april, MGC95053, TNFSF12-TNFSF13, TNFSF13, MGC128565, tnf13

Klonalität: Polyklonal

Wirt: Kaninchen

Applikation: ELISA, Blockierende Antikörper (Inhibition), Western Blot (WB)

Produktnummer: ABIN636631

Produktbeschreibung

Weitere Bezeichnung: APRIL

Immunogen: APRIL antibody was raised in rabbit using highly pure recombinant human APRIL as the immunogen.

Beschreibung: APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA. APRIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor.

Molekulargewicht: 21.9 kDa (predicted detection band MW)

Anwendungen

Reinheit: Affinity Purified

Buffer: Lyophilized from PBS, pH 7.2.

Lagerung: Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C. Avoid repeated freeze/thaw cycles.

Forschungsgebiet: Krebs, Zellzyklus, Angeborene Immunität, Zytokine