SNAP23 Antikörper (C-Term)

Produktnummer ABIN569620

Dieser Ziege Polyklonal Antikörper detektiert spezifisch SNAP23 in WB und EIA. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Hund und Kaninchen.

Kurzübersicht für SNAP23 Antikörper (C-Term) (ABIN569620)

Target: SNAP23 (Synaptosomal-Associated Protein, 23kDa (SNAP23))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser SNAP23 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-SNAP23 Antikörper

Bindungsspezifität: C-Term

Sequenz: C-TDKADTNRDR

Spezifität: This antibody is expected to recognize both isoforms (NP_003816.2, NP_570710.1). Amino acid numbering in name refers to NP_003816.2 sequence.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Dog, Cow, Rabbit.
Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the C Terminus of the protein sequence according to NP_003816.2, NP_570710.1. Genename: SNAP23

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SNAP23

Target: SNAP23 (Synaptosomal-Associated Protein, 23kDa (SNAP23))

Andere Bezeichnung: SNAP23

Hintergrund: Synaptosomal-associated proteins (SNAPs) are cytosolic proteins that play a key role in in the process of membrane fusion in intracellular vesicle trafficking. In eukaryotic cells, the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex is critical to membrane docking and fusion and is believed to impart some degree of specificity between vesicle SNARE (v-SNARE) and target organelle SNARE (t-SNARE). In neurons and neuroendocrine cells, the SNARE complex consists of the integral membrane proteins VAMP (vesicle-associated membrane protein), syntaxin and SNAP-25. In non-neuronal tissue, a SNAP-25 homolog, SNAP-23, functionally replaces SNAP-25 in the SNARE complex. Studies show that VAMP, syntaxin and SNAP-23 are required for SNARE function and that this complex exists as a heterotrimer of the three proteins. In insulin signalling pathways, studies suggest that the translocation of GLUT4 in adipocytes requires that functional SNAP-23 be present in SNARE complexes.Synonyms: SNAP-23, Synaptosomal-associated protein 23, Vesicle-membrane fusion protein SNAP-23

Gen-ID: 8773

NCBI Accession: NP_003816

UniProt: O00161