PCSK5 Antikörper (Middle Region)

Produktnummer ABIN502400

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-PCSK5 Antikörper wird verwendet zum Nachweis von PCSK5 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Pferd und Kaninchen. Er wurde validiert für WB.

Kurzübersicht für PCSK5 Antikörper (Middle Region) (ABIN502400)

Target: PCSK5 (Proprotein Convertase Subtilisin/kexin Type 5 (PCSK5))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCSK5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PCSK5 Antikörper

Bindungsspezifität: Middle Region

Sequenz: CAGAGADGCI NCTEGYFMED GRCVQSCSIS YYFDHSSENG YKSCKKCDIS

Homologie: Cow: 100%, Dog: 100%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against PCSK5. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PCSK5

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 913 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PCSK5 Antikörper (ABIN502400)

Szumska, Pieles, Essalmani, Bilski, Mesnard, Kaur, Franklyn, El Omari, Jefferis, Bentham, Taylor, Schneider, Arnold, Johnson, Tymowska-Lalanne, Stammers, Clarke, Neubauer, Morris, Brown, Shaw-Smith, Cama, Capra, Ragoussis, Constam, Seidah, Prat, Bhattacha: "VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5." in: Genes & development, Vol. 22, Issue 11, pp. 1465-77, (2008) (PubMed).

Details zu PCSK5

Target: PCSK5 (Proprotein Convertase Subtilisin/kexin Type 5 (PCSK5))

Andere Bezeichnung: PCSK5

Hintergrund: PCSK5 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. PCSK5 mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Two alternatively spliced transcripts are described for this gene but only one has its full length nature known.The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Two alternatively spliced transcripts are described for this gene but only one has its full length nature known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: PC5, PC6, PC6A, SPC6
Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-8, KRTAP10-7, LCE3C, KRTAP4-12, NUFIP2, GLRX3, STK16, MEOX2, KRTAP5-9, env, Hoxa1, ATN1, UBC, CACNA1A, APPBP2, AMH, REN, PTPRM, PMCH, ITGA6,
Protein Size: 913

Molekulargewicht: 89 kDa

Gen-ID: 5125

NCBI Accession: NM_006200, NP_006191

UniProt: Q92824

Pathways: Neurotrophin Signalübertragung, Regulation of Systemic Arterial Blood Pressure by Hormones