ZC3H12A Antikörper (Center)

Produktnummer ABIN501151

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ZC3H12A in WB und EIA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für ZC3H12A Antikörper (Center) (ABIN501151)

Target: ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZC3H12A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-ZC3H12A Antikörper

Bindungsspezifität: Center

Spezifität: This antibody detects human ZC3H12A.

Aufreinigung: Affinity chromatography

Immunogen: ZC3H12A antibody was raised against a 17 amino acid peptide near the center of human ZC3H12A.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu ZC3H12A

Target: ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))

Andere Bezeichnung: ZC3H12A

Hintergrund: ZC3H12A, also known as MCPIP, is an essential member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation and may be involved in host immunity and inflammatory diseases. ZC3H12A has RNase activity that prevents some immune disorders by directly affecting the mRNA stability of interleukins such as IL-6 and IL12p40. Mice lacking the ZC3H12A gene suffered from severe anemia, and most dies within 12 weeks. Overexpression of ZC3H12A causes ER stress and induces a number of genes involved in apoptosis and autophagy, including JNK, PUMA, and beclin-1 in cardiac myoblasts, leading to cell death. ZC3H12A can also induce adipogenesis in 3T3-L1 pre-adipocytes in the absence of PPAPg, demonstrating the complex roles ZC3H12A plays.Synonyms: MCP-induced protein 1, MCPIP, MCPIP1, Ribonuclease ZC3H12A, Zinc finger CCCH domain-containing protein 12A

Gen-ID: 80149

NCBI Accession: NP_079355

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of fat Cell Differentiation