Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) Antikörper

Antigen: Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK)

Synonyme: DP5, HARAKIRI, Bid3, AI838259, harakiri

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Western Blot (WB)

Produktnummer: ABIN499950

Produktbeschreibung

Produktmerkmale: Synonyms: Neuronal death protein DP5, BID3, Activator of apoptosis harakiri, BH3-interactingdomain-containing protein 3

Weitere Bezeichnung: Harakiri / HRK

Gen-ID: 8739

Swiss-Prot: O00198

Immunogen: HRK antibody was raised against a 15 amino acid peptide from near the center of HumanHrk (ABIN499949).

Kreuzreaktivität: Human, Maus

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Apoptosis plays a major role in normal organism development, tissue homeostasis, andremoval of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3(BH3)-only group of the Bcl-2 family of proteins, was also identified as novel proteininduced during programmed neuronal death. It lacks significant homology to other Bcl-2family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 andBcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, orBcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previouslyreported for Bcl-2 and Bcl-XL. Despite its predicted molecular weight, Hrk often migrates at12-15 kDa.

Spezifität: This antibody recognizes HRK. Species: Human, Mouse. Others not tested. Add. Information: Blocking peptide available: ABIN499949

Anwendungen

Applikationshinweise: ELISA. Western Blot: 2.5-5 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Reinigung: Aff - Purified

Buffer: PBS containing 0.02% Sodium Azide

Lagerung: Store the antibody undiluted at 2-8°C. Shelf life: one year from despatch.

Beschränkungen: Nur für Forschungszwecke einsetzbar