FASTK Antikörper

Produktnummer ABIN498486

Der Kaninchen Polyklonal anti-FASTK Antikörper (ABIN498486) detektiert spezifisch FASTK in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für FASTK Antikörper (ABIN498486)

Target: FASTK (Fas-Activated serine/threonine Kinase (FASTK))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FASTK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FASTK Antikörper

Spezifität: This antibody detects endogenous levels of FAST protein. (region surrounding Arg410)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: PBS, pH ~7.2, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu FASTK

Target: FASTK (Fas-Activated serine/threonine Kinase (FASTK))

Andere Bezeichnung: FAST Kinase

Hintergrund: The Human homolog FAST-1 and the corresponding mouse homolog, designated FAST-2, share significant sequence homology with xFAST-1, including a conserved N-terminal forkhead domain that consists of 110 amino acid residues and is essential for binding DNA and regulating transcription in embryogenesis, in tumorigenesis and in the maintenance of differentiated cell states. FAST-1 and FAST-2 also contain a distinct C-terminal Smad interaction domain that is required for the association with various Smad proteins, including Smad2, Smad3 and Smad4. Expression of FAST-1 and FAST-2 is predominantly observed during early development, with lower levels detected in adult tissues. FAST-1 and FAST-2 mediated DNA binding is attenuated by both TFGβ and activin, indicating that these FAST proteins mediate TFGβ induced signal transduction.Synonyms: FASTK, Fas-activated serine/threonine kinase

Molekulargewicht: approx. 60 kDa

Gen-ID: 10922

NCBI Accession: NP_006703

UniProt: Q14296