AKAP1 Antikörper

Produktnummer ABIN498433

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch AKAP1 in WB, IF und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für AKAP1 Antikörper (ABIN498433)

Target: AKAP1 (A Kinase (PRKA) Anchor Protein 1 (AKAP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AKAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-AKAP1 Antikörper

Spezifität: This antibody detects endogenous levels of AKAP149 protein. (region surrounding asn306)

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity-Chromatography using epitope-specific immunogen

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu AKAP1

Target: AKAP1 (A Kinase (PRKA) Anchor Protein 1 (AKAP1))

Andere Bezeichnung: AKAP1

Hintergrund: The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. This family of proteins has been designated A-kinase anchoring proteins (AKAP). Members of this family, including MAP2 (microtubule-associated protein 2), neuronally expressed AKAP 79 and AKAP 150, and the DNA binding AKAP 95, display differential tissue specificity and localization. Evidence suggests that AKAP 79 and AKAP 150 are both capable of anchoring PKA to postsynaptic densities (PSD), which are a network of proteins located on the internal surfaces of excitatory synapses.Synonyms: A kinase anchor protein 1 mitochondrial, A-kinase anchor protein 149 kDa, AKAP-1, AKAP149, Dual specificity A-kinase-anchoring protein 1, PRKA1, Protein kinase A-anchoring protein 1, Spermatid A-kinase anchor protein 84

Molekulargewicht: approx. 90 kDa

Gen-ID: 8165

NCBI Accession: NP_003479

UniProt: Q92667

Pathways: Synaptic Membrane