PRKG2 Antikörper

Produktnummer ABIN498430

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PRKG2 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für PRKG2 Antikörper (ABIN498430)

Target: PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRKG2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PRKG2 Antikörper

Spezifität: This antibody detects endogenous levels of cGKii protein. (region surrounding Asp412)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PRKG2

Target: PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))

Andere Bezeichnung: CGK2

Hintergrund: CGKII (cGMP-dependent protein kinase type II) is a major receptor of intracellular cGMP, and mediates a plethora of physiological responses. cGKII has a predicted molecular weight of 86 kD,a and contains a conserved leucine zipper motif at the amino terminus. It is expressed in small intestine, colon, prostate, and human brain tissues, and the cGKII gene maps to chromosome 4q13.1-q21.1. cGKII has been shown to regulate the ion transport system in the intestine. Myristoylation of the penultimate glycine in cGKII appears to be essential for directing cGKII to the membrane, since cGKII is devoid of any hydrophobic transmembrane domains. The translocation of cGKII from the cytosol to the membrane allows it to function properly in regulating intestinal ion transport.Synonyms: PRKG2, PRKGR2, Type II cGMP-dependent protein kinase, cGKII, cGMP-dependent protein kinase 2

Molekulargewicht: approx. 90 kDa

Gen-ID: 5593

NCBI Accession: NP_006250

UniProt: Q13237