HES6 Antikörper

Produktnummer ABIN498352

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch HES6 in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für HES6 Antikörper (ABIN498352)

Target: HES6 (Hairy and Enhancer of Split 6 (HES6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HES6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-HES6 Antikörper

Spezifität: This antibody detects endogenous levels of HES-6 protein. (region surrounding Ala6)

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu HES6

Target: HES6 (Hairy and Enhancer of Split 6 (HES6))

Andere Bezeichnung: HES6

Hintergrund: The Drosophila hairy and enhancer of split genes encode basic helix-loophelix (bHLH) transcriptional repressors that function in the notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of groucho, and this interaction is mediated by the carboxy-terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N-box (CACNAG) as opposed to the E-box (CANNTG). HES2 binds to both N- and E-box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues.Synonyms: BHLHB41, C-HAIRY1, Class B basic helix-loop-helix protein 41, Hairy and enhancer of split 6, Transcription cofactor HES-6

Molekulargewicht: approx. 30 kDa

Gen-ID: 55502

NCBI Accession: NP_061115

UniProt: Q96HZ4