SIPA1 Antikörper (N-Term)

Produktnummer ABIN401404

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SIPA1 in WB, IHC (p) und EIA. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für SIPA1 Antikörper (N-Term) (ABIN401404)

Target: SIPA1 (Signal-Induced Proliferation-Associated 1 (SIPA1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIPA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-SIPA1 Antikörper

Bindungsspezifität: N-Term

Kreuzreaktivität (Details): Species reactivity (expected):Human, Rat.
Species reactivity (tested):Mouse.

Aufreinigung: Affinity chromatography

Immunogen: Synthetic peptide corresponding to a region near the amino terminus of mouse Sipa1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1/20,000. Western Blot: 1/1,000 - 1/5,000. Immunohistochemistry: 1.25 - 2.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.25 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu SIPA1

Target: SIPA1 (Signal-Induced Proliferation-Associated 1 (SIPA1))

Andere Bezeichnung: SIPA1 / SPA1

Hintergrund: Sipa1 (signal-induced proliferation associated gene 1) is a mitogen-induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. Sipa1 is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.Synonyms: GTPase-activating protein Spa-1, Signal-induced proliferation-associated protein 1, Sipa-1, Spa-1, p130 SPA-1

Gen-ID: 10090

UniProt: P46062

Pathways: Response to Water Deprivation