RAB11 Family Interacting Protein 3 (Class II) (RAB11FIP3) Antikörper

Antigen: RAB11 Family Interacting Protein 3 (Class II) (RAB11FIP3)

Synonyme: KIAA0665, Rab11-FIP3, MGC47508, mKIAA0665, D030060O14Rik, LRRGT00043, RGD1308952, MNDPK, rab11fip3, zC153C20.4

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Western Blot (WB)

Produktnummer: ABIN401388

Produktbeschreibung

Produktmerkmale: Synonyms: Rab11-FIP3, FIP3-Rab11, Arfophilin-1, ARFO1, Eferin, KIAA0665, Rab11 family-interactingprotein 3, MU-MB-17.148

Weitere Bezeichnung: RAB11FIP3

Swiss-Prot: O75154

Immunogen: Recombinant protein corresponding to amino acids spanning the carboxyl terminalone-third of human FIP3

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Rab11 Family-Interacting Protein 3 (FIP3)/Arfophilin-1 and FIP4/Arfophilin-2 are dualeffectors for Rab11 and the ADP-ribosylation factor Arf6. Rab11 and Arf6 are involved inmembrane delivery from recycling endosomes to the plasma membrane duringcytokinesis. The dual Rab11/Arf6 binding proteins, FIP3 and FIP4, function in the delivery ofrecycling endosomes to the cleavage furrow and are, together with Rab11, essential forcompletion of abscission, the terminal step of cytokinesis. An interaction betweenRab11-FIP3 and ASAP1 has also been identified (personal communication, P. Randazzo,CCR-NCI, Bethesda, MD). ASAP1 is an Arf GTPase-activating protein that has beenimplicated in the invasive properties of uveal melanoma and mammary carcinoma.

Spezifität: This antibody is directed against FIP3 protein. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat.

Anwendungen

Applikationshinweise: ELISA: 1/1,000 - 1/3,000. Western Blot: 1/200 - 1/2,000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Konzentration: 1.19 mg/ml (by UV absorbance at 280 nm)

Reinigung: Aff - Purified

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing0.01% (w/v) Sodium Azide

Lagerung: Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Beschränkungen: Nur für Forschungszwecke einsetzbar