ZIC2 Antikörper (AA 189-206)

Produktnummer ABIN401287

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ZIC2 in WB und EIA. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Maus, Hund und Schimpanse.

Kurzübersicht für ZIC2 Antikörper (AA 189-206) (ABIN401287)

Target: ZIC2

Reaktivität: Human, Ratte, Maus, Hund, Schimpanse

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZIC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-ZIC2 Antikörper

Bindungsspezifität: AA 189-206

Spezifität: This antibody is directed against Mouse ZIC2 protein. A BLAST analysis was used to suggest reactivity with this protein from Human, Chimpanzee, Mouse, Rat and Dog based on 100 % homology for the immunogen sequence. Expect cross reactivity with ZIC2 from Chicken, Zebrafish and Frog as the core 16 amino acid residues within the immunogen sequence show very high degrees of homology with ZIC2 from these sources. Cross reactivity with ZIC2 homologues from other sources has not been determined.

Kreuzreaktivität (Details): Species reactivity (expected):Human, Chimpanzee, Mouse, Rat, Canine, Chicken, Zebrafish, Frog.
Species reactivity (tested):Mouse.

Aufreinigung: Affinity Chromatography

Immunogen: Synthetic peptide corresponding amino acids 189-206 of Mouse ZIC-2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10,000 - 1/50,000. Western Blot: 1/500 - 1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at-20 °C.

Details zu ZIC2

Target: ZIC2

Andere Bezeichnung: ZIC2

Hintergrund: ZIC2 (also known as zinc finger protein of the cerebellum 2, HPE5, Zic family member 2 and odd-paired Drosophila homolog) is a nuclear protein that functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. In mouse, knockout of Zic1 leads to aplasia of cerebellum and skeletal abnormalities. Mutation in Zic2 and Zic3 in mouse and/or human cause holoprosencephaly and heterotaxis, respectively. Holoprosencephaly is the most common structural anomaly of the human brain.Synonyms: Zinc finger protein ZIC 2, Zinc finger protein of the cerebellum 2

Gen-ID: 7546

NCBI Accession: NP_009060

UniProt: O95409

Pathways: Tube Formation