PTPN21 Antikörper (AA 751-780)

Produktnummer ABIN392838

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-PTPN21 Antikörper (Klon RB0623-0624) (ABIN392838) detektiert spezifisch PTPN21 in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für PTPN21 Antikörper (AA 751-780) (ABIN392838)

Target: PTPN21 (Protein tyrosine Phosphatase, Non-Receptor Type 21 (PTPN21))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTPN21 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB0623-0624

Produktdetails anti-PTPN21 Antikörper

Bindungsspezifität: AA 751-780

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PTPD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-780 amino acids from the Central region of human PTPD1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PTPN21 Antikörper (ABIN392838)

Fox, Storey: "BMX Negatively Regulates BAK Function, Thereby Increasing Apoptotic Resistance to Chemotherapeutic Drugs." in: Cancer research, Vol. 75, Issue 7, pp. 1345-55, (2015) (PubMed).

Details zu PTPN21

Target: PTPN21 (Protein tyrosine Phosphatase, Non-Receptor Type 21 (PTPN21))

Andere Bezeichnung: PTPD1

Hintergrund: PTPD1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.

Molekulargewicht: 133281

Gen-ID: 11099

NCBI Accession: NP_008970

UniProt: Q16825