TRPM7 Antikörper (C-Term)

Produktnummer ABIN392614

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TRPM7 in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human und Maus. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für TRPM7 Antikörper (C-Term) (ABIN392614)

Target: TRPM7 (Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRPM7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB3469-3470

Produktdetails anti-TRPM7 Antikörper

Bindungsspezifität: AA 1821-1850, C-Term

Homologie: Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This TRPM7 (CHAK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1821-1850 amino acids from the C-terminal region of human TRPM7 (CHAK1).

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-TRPM7 Antikörper (ABIN392614)

Inoue, Branigan, Xiong: "Zinc-induced neurotoxicity mediated by transient receptor potential melastatin 7 channels." in: The Journal of biological chemistry, Vol. 285, Issue 10, pp. 7430-9, (2010) (PubMed).

Gavenis, Schumacher, Schneider, Eisfeld, Mollenhauer, Schmidt-Rohlfing: "Expression of ion channels of the TRP family in articular chondrocytes from osteoarthritic patients: changes between native and in vitro propagated chondrocytes." in: Molecular and cellular biochemistry, Vol. 321, Issue 1-2, pp. 135-43, (2009) (PubMed).

Details zu TRPM7

Target: TRPM7 (Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7))

Andere Bezeichnung: TRPM7 (CHAK1)

Hintergrund: TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[supplied by OMIM]

Molekulargewicht: 212697

Gen-ID: 54822

NCBI Accession: NP_060142

UniProt: Q96QT4