LATS2 Antikörper (AA 228-258)

Produktnummer ABIN391034

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-LATS2 Antikörper wird verwendet zum Nachweis von LATS2 in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für LATS2 Antikörper (AA 228-258) (ABIN391034)

Target: LATS2 (LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LATS2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB3032

Produktdetails anti-LATS2 Antikörper

Bindungsspezifität: AA 228-258

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This LATS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-258 amino acids from the Central region of human LATS2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-LATS2 Antikörper (ABIN391034)

Yamashita, Yamamoto, Mimori, Nishida, Takahashi, Haraguchi, Tanaka, Shibata, Sekimoto, Ishii, Doki, Mori: "MicroRNA-372 is associated with poor prognosis in colorectal cancer." in: Oncology, Vol. 82, Issue 4, pp. 205-12, (2012) (PubMed).

Details zu LATS2

Target: LATS2 (LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))

Andere Bezeichnung: LATS2

Hintergrund: LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. This protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.

Molekulargewicht: 120136

Gen-ID: 26524

NCBI Accession: NP_055387

UniProt: Q9NRM7