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UBE2K Antikörper (C-Term)

UBE2K Reaktivität: Human, Maus, Hund, Rind (Kuh), Schwein WB Wirt: Ziege Polyclonal unconjugated
Produktnummer ABIN374290
  • Target Alle UBE2K Antikörper anzeigen
    UBE2K (Ubiquitin-Conjugating Enzyme E2K (UBE2K))
    Bindungsspezifität
    • 8
    • 8
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 46
    • 21
    • 18
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    Human, Maus, Hund, Rind (Kuh), Schwein
    Wirt
    • 43
    • 2
    • 2
    • 1
    Ziege
    Klonalität
    • 46
    • 2
    Polyklonal
    Konjugat
    • 25
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser UBE2K Antikörper ist unkonjugiert
    Applikation
    • 37
    • 26
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    C-SWDVETATEL LLSN
    Spezifität
    This antibody recognizes UBE2K/HIP2 (C-term). It is expected to recognise all reported isoforms.
    Kreuzreaktivität (Details)
    Species reactivity (expected):Mouse, Canine (Dog), Pig and Cow.
    Species reactivity (tested):Human.
    Aufreinigung
    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
    Immunogen
    Peptide from C Terminus of the protein sequence according to NP_005330.1, NP_001104582.1, NP_001104583.1. Genename: UBE2K
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    Discover our top product UBE2K Primärantikörper
  • Applikationshinweise
    Peptide ELISA: Limit Dilution: 1/2000. Western blot: 1-3 μg/mL. Approx 24 kDa band observed in Jurkat cell lysates (CalculatedMW of 22.4 kDa according to NP_005330).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at (in aliquots) at -20 °C.
  • Target
    UBE2K (Ubiquitin-Conjugating Enzyme E2K (UBE2K))
    Andere Bezeichnung
    HIP2 / UBE2K (UBE2K Produkte)
    Synonyme
    E2-25K antikoerper, HIP2 antikoerper, HYPG antikoerper, LIG antikoerper, UBC1 antikoerper, E2-25k antikoerper, Hip2 antikoerper, Hypg antikoerper, Lig antikoerper, e2-25k antikoerper, hip2 antikoerper, hypg antikoerper, lig antikoerper, AW492011 antikoerper, D5Ertd601e antikoerper, ube2k antikoerper, zgc:103472 antikoerper, zgc:110791 antikoerper, ubiquitin conjugating enzyme E2 K antikoerper, ubiquitin-conjugating enzyme E2K antikoerper, ubiquitin conjugating enzyme E2 K S homeolog antikoerper, ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast) antikoerper, ubiquitin-conjugating enzyme E2Ka (UBC1 homolog, yeast) antikoerper, UBE2K antikoerper, Ube2k antikoerper, ube2k.S antikoerper, ube2k antikoerper, ube2kb antikoerper, ube2ka antikoerper
    Hintergrund
    The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. HIP2 belongs to the ubiquitin conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis. Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short lived and abnormal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid bearing macrophages through ubiquitination and subsequent degradation of p53.Synonyms: E2(25K), E2-25K, HIP-2, Huntingtin-interacting protein 2, LIG, Ubiquitin carrier protein, Ubiquitin-conjugating enzyme E2 K, Ubiquitin-protein ligase
    Gen-ID
    3093
    NCBI Accession
    NP_005330
    UniProt
    P61086
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