ALS2 Antikörper (C-Term)

Produktnummer ABIN374168

Produktdetails anti-ALS2 Antikörper

Target: ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser ALS2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Sequenz: LKACYYQIQR EKLN

Spezifität: This antibody detects Alsin / ALS2 at C-term.

Aufreinigung: Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Immunogen: Peptide from C Terminus of the protein sequence according to NP_065970.2 Genename: ALS2

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Limit dilution 1: 8000. Immunohistochemistry: 3-5 μg/mL. In paraffin embedded Human Cortex shows pixulatecytoplasm staining in some neuronal cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.

Details zu ALS2

Target: ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))

Andere Bezeichnung: Alsin / ALS2 (ALS2 Produkte)

Synonyme: als2 antikoerper, si:dkey-33m14.1 antikoerper, ALS2CR6 antikoerper, ALSJ antikoerper, IAHSP antikoerper, PLSJ antikoerper, 3222402C23Rik antikoerper, 9430073A21Rik antikoerper, Als2cr6 antikoerper, Alsin antikoerper, mKIAA1563 antikoerper, amyotrophic lateral sclerosis 2a (juvenile) antikoerper, alsin antikoerper, ALS2, alsin Rho guanine nucleotide exchange factor antikoerper, amyotrophic lateral sclerosis 2 (juvenile) antikoerper, als2a antikoerper, CpipJ_CPIJ008258 antikoerper, CpipJ_CPIJ008260 antikoerper, ALS2 antikoerper, Als2 antikoerper

Hintergrund: ALS2 specifically binds to, and functions as a guanine nucleotide exchange factor (GEF) for the small GTPase RAB5. ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Loss of ALS2 function might underlie neuronal dysfunction and degeneration in a number of motor neuron diseases.Synonyms: ALS2CR6, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein, Amyotrophic lateral sclerosis protein 2, KIAA1563

Gen-ID: 57679

NCBI Accession: NP_065970

UniProt: Q96Q42

Pathways: Skeletal Muscle Fiber Development