GRIN1/NMDAR1 Antikörper

Produktnummer ABIN362999

Der Kaninchen Polyklonal anti-GRIN1/NMDAR1 Antikörper wird verwendet zum Nachweis von GRIN1/NMDAR1 in Proben von Human, Ratte und Maus. Er wurde validiert für IF.

Kurzübersicht für GRIN1/NMDAR1 Antikörper (ABIN362999)

Target: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRIN1/NMDAR1 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF)

Produktdetails anti-GRIN1/NMDAR1 Antikörper

Spezifität: The antibody detects endogenous level of total Caveolin-2 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.

Immunogen: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1:500-1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: 4 °C/-20 °C

Details zu GRIN1/NMDAR1

Target: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Andere Bezeichnung: NMDAR1

Hintergrund: NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.

Molekulargewicht: 22 kDa

Pathways: Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity