KCNQ4 Antikörper (AA 2-77)

Produktnummer ABIN361768

Dieser Maus Monoklonal Antikörper detektiert spezifisch KCNQ4 in WB, IHC, IP, ICC, IF und AA. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 3+ Publikationen zitiert.

Kurzübersicht für KCNQ4 Antikörper (AA 2-77) (ABIN361768)

Target: KCNQ4 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KCNQ4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Antibody Array (AA)

Klon: N43-6 (Formerly S43-6)

Produktdetails anti-KCNQ4 Antikörper

Bindungsspezifität: AA 2-77

Spezifität: Detects ~77 kDa.

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Protein G Purified

Immunogen: Fusion protein amino acids 2-77 of human KCNQ4

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

• WB (1:1000)
• IHC (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Kommentare:

1 μg/ml of ABIN361768 was sufficient for detection of KCNQ4 in 10 μg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Referenzen für anti-KCNQ4 Antikörper (ABIN361768)

Marchetta, Möhrle, Eckert, Reimann, Wolter, Tolone, Lang, Wolters, Feil, Engel, Paquet-Durand, Kuhn, Knipper, Rüttiger: "Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss." in: Frontiers in aging neuroscience, Vol. 12, pp. 83, (2020) (PubMed).

Jeng, Ceriani, Hendry, Johnson, Yen, Simmons, Kros, Marcotti: "Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea." in: The Journal of physiology, Vol. 598, Issue 1, pp. 151-170, (2020) (PubMed).

Wolter, Möhrle, Schmidt, Pfeiffer, Zelle, Eckert, Krämer, Feil, Pilz, Knipper, Rüttiger: "GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing." in: Frontiers in neural circuits, Vol. 12, pp. 65, (2019) (PubMed).

Details zu KCNQ4

Target: KCNQ4 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4))

Andere Bezeichnung: KCNQ4

Hintergrund: The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability (1), particularly in sensory cells of the cochlea (2). The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug (3).

Gen-ID: 9132

NCBI Accession: NP_004691

UniProt: P56696

Pathways: Sensory Perception of Sound