Discs, Large Homolog 4 (Drosophila) (DLG4) Antikörper

Antigen: Discs, Large Homolog 4 (Drosophila) (DLG4)

Synonyme: PSD95, SAP90, SAP-90, FLJ97752, FLJ98574, DAP2, SAPAP2, Dlgh4, PSD-95, SAP90A, Sap90, 11, anon-EST:Posey93, anon-WO03040301.258, anon-WO03040301.260, anon-WO03040301.268, CG1725, CG1730, CPD, d. lg.-1, Discs-large, dlg, Dlg, DLG, dlg-1, dlg-A, Dlg-A, DLG-A, Dlg1, dlgA, DlgA, DmelCG1725, Drodlg, l(1)10Bf, l(1)bwn, l(1)d.lg-1, l(1)d.lg.-1, l(1)discs large, l(1)dlg, l(1)dlg-1, l(1)dlg1, l(1)G0276, l(1)G0342, l(1)G0456, l(1)G19, l(1)l.pr.-2, l(1)L11, l(1)lpr-2, misb, SAP97, Sapap2, 6430596N04Rik, dlgh4, psd95, sap90, sap-90, LLGL1

Klonalität: Monoklonal (6G6)

Wirt: Maus

Reaktivität: Maus, Ratte (Rattus), Rind (Kuh)

Applikation: Western Blot (WB), Immunzytochemie (ICC)

Produktnummer: ABIN361694

Produktbeschreibung

Produktmerkmale: Detects a ~100kDa protein corresponding to the molecular mass of PSD-95 on SDS PAGE immunoblots. An additional protein of >100kDa is also detected. Additional cross-reactive bands are detected at ~75kDa and 50kDa in rat and mouse samples.

Weitere Bezeichnung: PSD95

Gen-ID: 29495

Swiss-Prot: P31016

Immunogen: Recombinant rat PSD-95

Format: Liquid

Isotyp: IgG2a  (Passende Sekundärantikörper)

Klon: 6G6

Beschreibung: Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex. These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins . Thus different PDZ domains of PSD-95 might be specialized for distinct functions .
Synonyms: DLG4, SAP90

Spezifität: Detects an ~100kDa protein corresponding to the apparent molecular mass of PSD-95 on SDS-PAGE immunoblots. An additional protein of >100 kDa is also detected. Additional cross-reactive bands are detected at ~75 kDa and 50 kDa in rat and mouse samples. Species cross-reactivity: Mouse, Rat, Bovine, Human.

Sensitivität: 1µg/ml was sufficient for detection of PSD-95 on 20µg rat brain tissue extract by ECL immunoblot analysis using Goat Anti-Mouse igG:HRP as the secondary.

Synonyme: PSD95, SAP90, SAP-90, FLJ97752, FLJ98574, DAP2, SAPAP2, Dlgh4, PSD-95, SAP90A, Sap90, 11, anon-EST:Posey93, anon-WO03040301.258, anon-WO03040301.260, anon-WO03040301.268, CG1725, CG1730, CPD, d. lg.-1, Discs-large, dlg, Dlg, DLG, dlg-1, dlg-A, Dlg-A, DLG-A, Dlg1, dlgA, DlgA, DmelCG1725, Drodlg, l(1)10Bf, l(1)bwn, l(1)d.lg-1, l(1)d.lg.-1, l(1)discs large, l(1)dlg, l(1)dlg-1, l(1)dlg1, l(1)G0276, l(1)G0342, l(1)G0456, l(1)G19, l(1)l.pr.-2, l(1)L11, l(1)lpr-2, misb, SAP97, Sapap2, 6430596N04Rik, dlgh4, psd95, sap90, sap-90, LLGL1

Anwendungen

Applikationshinweise: 1:250 (WB)

Konzentration: 1 mg/mL

Reinigung: Protein G Purified

Buffer: PBS pH7.4, 50% glycerol

Lagerung: -20 °C

Storage Shipping Temp Max: Blue Ice or 4 °C

Forschungsgebiet: Neurologie

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

PSD95 (6G6), Dissociated hippocampal neurons. Courtesy of Mary Kennedy, Caltech

PSD95 in rat hippocampus

PSD95 (6G6), HaCaT cells