GABA Transporter 1 (GAT1) Antikörper

Antigen: GABA Transporter 1 (GAT1)

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Ratte (Rattus)

Applikation: Western Blot (WB), Immunhistochemie (IHC)

Produktnummer: ABIN361450

Produktbeschreibung

Weitere Bezeichnung: GABA Transporter (GAT) 1

Format: Affinity-purified

Beschreibung: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003). Anti-GAT1 Western blot of rat hippocampal homogenate showing specific immunolabeling of the~ 67k GAT-1 protein.

Spezifität: Specific for the ~67k GAT-1 protein. Immunolabeling is blocked by the peptide used as antigen.

Anwendungen

Applikationshinweise: Recommended Dilution: WB: 1:1000 IHC: 1:100-1:200 Quality Control: Western blots performed on each lot.

Reinigung: Prepared from rabbit serum by affinity purification.

Lagerung: Store at -20 °C, stable for 1 year

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western blots of rat hippocampal homogenate showing specific immunolabeling of the~ 67k GAT-1 protein.