GRIN1/NMDAR1 Antikörper (AA 1-564)

Produktnummer ABIN361405

Dieser Maus Monoklonal Antikörper detektiert spezifisch GRIN1/NMDAR1 in WB, IHC, ELISA und ICC. Es zeigt Reaktivität gegenüber Proben von Ratte. Es wurde in 4+ Publikationen zitiert.

Kurzübersicht für GRIN1/NMDAR1 Antikörper (AA 1-564) (ABIN361405)

Target: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GRIN1/NMDAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Klon: R1JHL

Produktdetails anti-GRIN1/NMDAR1 Antikörper

Bindungsspezifität: AA 1-564

Spezifität: Specific for endogenous levels of the ~120 kDa NR1 subunit of the NMDA receptor.

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Our Anti-NMDA NR1 Subunit Antibody primary antibody is mouse monoclonal. It detects human, mouse, and rat NMDA NR1 Subunit and is culture supernatant. It is great for use in ELISA, WB, IHC, ICC.

Aufreinigung: Culture supernatant.

Immunogen: Fusion protein containing amino acids 1-564 of the NR1 subunit of rat NMDA receptor.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Dilution Range: IP: 3 μg per 200 μg lysate

Dilution Range: ICC: 1:10

Dilution Range: WB Brain: 1:1000

Dilution Range: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Reconstitute in 50 μl phosphate buffered saline (PBS: 137 mM NaCl, 7.5 mM Na2HPO4, 2.7 mM KCl, 1.5 mM KH2PO4, pH 7.4) before use. After reconstitution it is recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Haltbarkeit: 12 months

Referenzen für anti-GRIN1/NMDAR1 Antikörper (ABIN361405)

Quillinan, Grewal, Deng, Shimizu, Yonchek, Strnad, Traystman, Herson: "Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia." in: Neuroscience, Vol. 284, pp. 555-65, (2014) (PubMed).

Hicklin, Wu, Radcliffe, Freund, Goebel-Goody, Correa, Proctor, Lombroso, Browning: "Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 16, pp. 6650-5, (2011) (PubMed).

Davies, Goebel-Goody, Coultrap, Browning: "Long term synaptic depression that is associated with GluR1 dephosphorylation but not alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization." in: The Journal of biological chemistry, Vol. 283, Issue 48, pp. 33138-46, (2008) (PubMed).

Zhang, Dong, Zhang, Ichinose, Wu, Culley, Crosby, Tanzi, Xie: "Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 17, pp. 4551-60, (2008) (PubMed).

Details zu GRIN1/NMDAR1

Target: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Andere Bezeichnung: GRIN1

Hintergrund:

Synonyms: GluN1 antibody, Glutamate [NMDA] receptor subunit zeta-1 antibody, Glutamate receptor ionotropic N methyl D aspartate 1 antibody, Glutamate receptor ionotropic N-methyl-D aspartate subunit 1 antibody, glutamate receptor ionotropic NMDA 1 antibody, Grin1 antibody, MRD8 antibody, N methyl D aspartate receptor antibody, N methyl D aspartate receptor channel subunit zeta 1 antibody, N methyl D aspartate receptor subunit NR1 antibody, N-methyl-D-aspartate receptor subunit NR1 antibody, NMD-R1 antibody, NMDA 1 antibody, NMDA R1 antibody, NMDAR1 antibody, NMDA receptor 1 antibody, NMDA1 antibody, NMDAR antibody, NMDZ1_HUMAN antibody, NR1 antibody

Description Logic: Our Anti-NMDA NR1 Subunit Antibody primary antibody is mouse monoclonal. It detects human, mouse, and rat NMDA NR1 Subunit and is culture supernatant. It is great for use in ELISA, WB, IHC, ICC.

Gene Name Alternatives: GRIN1

Molekulargewicht: 120 kDa

Gen-ID: 24408

UniProt: P35439

Pathways: Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity