NMDA Receptor, NR2B Subunit (0) (N-Term) Antikörper

Antigen: NMDA Receptor, NR2B Subunit (0)

Epitope: N-Term

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Ratte (Rattus)

Applikation: Western Blot (WB), Immunhistochemie (IHC)

Produktnummer: ABIN361399

Produktbeschreibung

Weitere Bezeichnung: NMDA Receptor, NR2B Subunit N-terminus

Format: Affinity-purified

Beschreibung: The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be clonedand it can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Overexpression of the NR2B-subunit of the NMDA receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression (Clayton et al., 2002a, Clayton et al., 2002b). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). Anti-NMDA Receptor, NR2B Subunit Western blot of 10 ug of rat hippocampal lysate showing specific immunolabeling of the ~180k NR2B subunit of the NMDA receptor.

Spezifität: Specific for the ~180k NR2B subunit of the NMDA receptor.

Anwendungen

Applikationshinweise: Recommended Dilution: WB: 1:1000 IHC: 1:500 Quality Control: Western blots performed on each lot.

Reinigung: Prepared from rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.

Lagerung: Store at -20 °C, stable for 1 year

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western blots of 10 ug of rat hippocampal lysate showing specific immunolabeling of the ~180k NR2B subunit of the NMDA receptor.