Thyroid Hormone Receptor, Alpha1/Alpha2 (THRA1/2) Antikörper

Antigen: Thyroid Hormone Receptor, Alpha1/Alpha2 (THRA1/2)

Synonyme: LOC397942, thra1, thra-A, nr1a1-A, THRB, NR1A2

Klonalität: Monoklonal (1718)

Wirt: Maus

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN361383

Produktbeschreibung

Weitere Bezeichnung: Thyroid Hormone Receptor, a1/a2-Isotype

Format: Affinity-purified

Isotyp: IgG2a  (Passende Sekundärantikörper)

Klon: 1718

Beschreibung: Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005, Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRa1, TRa2, TR 1 and TR 2. TRa1, TR 1 and TR 2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005). Anti-Thyroid Hormone Receptor, a1/a2-Isotype Western blot of hippocampal lysate showing specific immunolabeling of the ~50k TR-a1 and the ~58k TR-a2 protein.

Spezifität: Specific for the ~50k TR-a1 and the ~58k TR-a2 protein.

Anwendungen

Applikationshinweise: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Reinigung: Prepared from mouse ascites by ammonium sulfate precipitation followed by affinity purification on a protein G column.

Lagerung: Store at -20 °C, stable for 1 year

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western blots of hippocampal lysate showing specific immunolabeling of the ~50k TR-a1 and the ~58k TR-a2 protein.