Periostin, Osteoblast Specific Factor (POSTN) (C-Term) Antikörper

Antigen: Periostin, Osteoblast Specific Factor (POSTN)

Synonyme: PN, OSF2, OSF-2, PDLPOSTN, MGC119510, MGC119511, periostin, RP11-412K4.1, PLF, Osf2, peri, AI747096, Periostin, MGC128214, pn, fa99h07, MGC153873, wu:fa99h07, wu:fc70f09, zgc:153873, LOC100008945, osf-2, pdlpostn

Epitope: C-Term

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Huhn

Applikation: Western Blot (WB), Immunhistochemie (IHC)

Produktnummer: ABIN361361

Produktbeschreibung

Weitere Bezeichnung: Periostin, C-terminal

Beschreibung: Periostin is a matricellular protein, i.e. an extracellular matrix protein that interacts both with other ECM proteins and with cell-surface receptors. Like many other matricellular proteins, the function of periostin is important both in embryonic development and in the remodeling of adult tissues in response to pathological insults. Periostin was originally isolated as an osteoblast-specific marker that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading (Kruzynska-Frejtag A. et al., 2004). Periostin has recently been shown to promote collagen fibrogenesis, inhibit differentiation of progenitor cells into cardiomyocytes and to be essential in maintaining the biomechanical properties of the adult myocardium (Norris et al., 2008) Anti-Periostin Western blot of rat lung lysate showing specific immunolabeling of the ~ 93 kDa periostin protein doublet.

Spezifität: Specific for the ~93 kDa periostin doublet in mouse lung extract. This antibody does not recognize the single heart form of periostin or the lowest molecular weight form of lung periostin. Consistent with the fact that this antibody is made against an alternatively spliced region of periostin, this antibody recognizes a subset of the forms of periostin recognized on Western blots by the Pan periostin antibody (Catalog number 1622-PERI) and also shows a distinctive staining pattern by immunohistochemistry (data not shown). The antibody works well for immunohistochemistry on paraformaldehyde-fixed sections with a simple antigen-retrieval protocol (incubate slides for 20 minutes at 90º C in 10 mM sodium citrate (pH 6.0)/ 0.1 % Tween-20). The antibody is expected to work on all mammalian , avian species.

Synonyme: PN, OSF2, OSF-2, PDLPOSTN, MGC119510, MGC119511, periostin, RP11-412K4.1, PLF, Osf2, peri, AI747096, Periostin, MGC128214, pn, fa99h07, MGC153873, wu:fa99h07, wu:fc70f09, zgc:153873, LOC100008945, osf-2, pdlpostn

Anwendungen

Applikationshinweise: Recommended Dilution: WB: 1:1,000 IHC: 1:100 Quality Control: Western blots performed on each lot.

Reinigung: Affinity purified rabbit serum.

Lagerung: Store at -20 °C, stable for 1 year

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western blots of rat lung lysate showing specific immunolabeling of the ~ 93 kDa periostin protein doublet.