Nuclear Pore Complex Antikörper

Antigen: Nuclear Pore Complex

Klonalität: Monoklonal (39C7)

Wirt: Maus

Reaktivität: Human, Maus, Ratte (Rattus), Hefe (Saccharomyces Cerevisiae)

Applikation: Immunfluoreszenz (IF)

Produktnummer: ABIN361356

Produktbeschreibung

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: 39C7

Beschreibung: The nuclear pore complex (NPC) is a very large structure made up of at least 50 different proteins that span the double membrane of the nuclear envelope functioning as a gateway for macromolecular traffic between the cytoplasm and the nucleus (Nakielny and Dreyfuss,1999). Discrete nuclear pore complex proteins or nucleoporins such as NUP98, NUP180 and p62 have been implicated in autoimmune disease and cancer. Patients with primary biliary cirrhosis (PBC) frequently produce autoantibodies against p62 and NUP180 (Wilken et al., 1993, Nesher et al., 2001) while NUP98 translocations have been found in patients with acute myelogenous leukemia (AML) (Jaju et al. 2001).

Spezifität: Reacts with a nuclear pore complex protein.

Anwendungen

Applikationshinweise: Recommended Dilution: IF: 1:50-1:100 Quality Control: Immunofluorescence performed on each lot.

Reinigung: Concentrated culture supernatant.

Lagerung: Store at -20 °C, stable for 1 year

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

HeLa cells were stained with anti-nuclear pore complex antibody (green), and chicken anti-vimentin (red).