IL33 Antikörper

Antigen: IL33

Klonalität: Monoklonal (4-00E-09)

Wirt: Maus

Reaktivität: Human

Applikation: ELISA, Western Blot (WB)

Produktnummer: ABIN361077

Produktbeschreibung

Immunogen: Recombinant human IL-33 (112-270aa), Accession / GI number: NP_254274

Isotyp: IgG2b, kappa chain  (Passende Sekundärantikörper)

Klon: 4-00E-09

Beschreibung: Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine and intracellular nuclear factor with transcriptional regulatory properties. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1.Concentration: 1 mg/ml

Anwendungen

Applikationshinweise: Recommended dilution 1:500

Konzentration: 1mg/ml

Reinigung: The antibody was purified from mouse ascitic fluids by protein-G affinity chromatography

Buffer: In Phosphate-Buffered Saline (pH7.4) with 0.1% Sodium Azide

Lagerung: Store at -20°, Aliquot to avoid repeated freezing and thawing.

Forschungsgebiet: Hormone, Zytokine

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-IL33 antibody