CD5 Antikörper (APC)

Produktnummer ABIN356199

Der APC-konjugierte Ratte Monoklonal anti-CD5 Antikörper (Klon 4H8E6) (ABIN356199) detektiert spezifisch CD5 in FACS, WB, IP, IHC (fro) und Func. Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für CD5 Antikörper (APC) (ABIN356199)

Target: CD5

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD5 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Klon: 4H8E6

Produktdetails anti-CD5 Antikörper (APC)

Spezifität: This antibody is specific to CD5/Lyt-1 (Mr. 67 kDa)

Produktmerkmale: Synonyms: Lymphocyte antigen T1/Leu-1, LEU1, T-cell surface glycoprotein CD5

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: Identification and enumeration of CD5+ cells (< / = 0.2 μg/10^6 cells). (Ref.15)Immunoprecipitation. (Ref.15)Immunohistochemistry on Frozen Sections. (Ref.15)T Cell Activation. (Ref.15)Western blotting. (Ref.15)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative and a stabilizing agent.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CD5

Target: CD5

Andere Bezeichnung: CD5

Hintergrund: CD5/Lyt-1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. (Ref.1-3) It has been identified as the major ligand of the B-cell antigen CD72. (Ref.4,5) The frequency of CD5+ B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells (reviewed in Ref.6). Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression. (Ref.7-12) It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors. (Ref.13,14)Synonyms: CD5, LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5

Gen-ID: 12507

UniProt: P13379