Ketocholesterol Antikörper

Antigen: Ketocholesterol

Klonalität: Monoklonal (35A)

Wirt: Maus

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro))

Produktnummer: ABIN335416

Produktbeschreibung

Weitere Bezeichnung: Ketocholesterol (7-KC)

Format: Lyophilized

Isotyp: IgG  (Passende Sekundärantikörper)

Klon: 35A

Beschreibung: Cholesterol oxidation products, especially 7-Ketocholesterol (7KC), have been the focus of much attention because they are present in human atherosclerotic plaque and display a wide range of atherogenic properties in vitro and to some extant in vivo. This antibody is specific for 7KC. This antibody is useful to detect 7KC in tissue samples. A frozen tissue sample is recommended for immunohistochemistry.

Spezifität: Specific for 7KC

Anwendungen

Applikationshinweise: Immunohistochemistry: It is recommended that the antibody be tried at 5-10 micro g/mL on frozen tissue. Not applicable to paraffin embedded tissues.

Konzentration: IgG concentration is 1mg/mL

Reinigung: Purified by Protein A.

Buffer: 10mM PBS containing 0.1 % NaN3 and 0.5% BSA.

Lagerung: Less than 20°C.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Immunohistochemical detection of 7KC in atherosclerotic aorta.

Publikationen

Publikationen: Larsson, Baird, Nyhalah et al.: "Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects." in: Free radical biology & medicine, Vol. 41, Issue 6, pp. 902-10, 2006 (PubMed).

Moreira, Larrayoz, Lee et al.: "7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation." in: Investigative ophthalmology & visual science, Vol. 50, Issue 2, pp. 523-32, 2009 (PubMed).