ITGA6 Antikörper

Produktnummer ABIN335350

Produktdetails anti-ITGA6 Antikörper

Target: ITGA6 (Integrin, alpha 6 (ITGA6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ITGA6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Spezifität: Human. A broad species reactivity is expected because of the conserved nature of the epitope.

Aufreinigung: Purified

Immunogen: 6B4 is a mouse monoclonal IgG1, kappa antibody derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with a synthetic peptide corresponding to a 34 amino acid stretch in the cytoplasmic domain of integrin alpha6B including an appending N-terminal cysteine: CSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKK coupled to keyhole limpet hemocyanin.

Klon: 6B4

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: 6B4 recognizes specifically the cytoplasmic domain of integrin subunit alpha6B. 6B4 stains the basement membrane zone of ducts and acini of salivary gland, kidney tubules, epithelium of colonic crypts and weakly stains sweat glands and sebaceous glands. 6B4 is suitable for immunoblotting, immunocytochemistry and immunohistochemistry on frozen tissues. Optimal antibody dilution should be determined by titration, recommended range is 1:50 - 1:100 for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:500 for immunoblotting applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: antibody in PBS containing 0.09% Sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-ITGA6 Antikörper (ABIN335350)

Hogervorst, Admiraal, Niessen, Kuikman, Janssen, Daams, Sonnenberg: "Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit." in: The Journal of cell biology, Vol. 121, Issue 1, pp. 179-91, (1993) (PubMed).

Details zu ITGA6

Target: ITGA6 (Integrin, alpha 6 (ITGA6))

Andere Bezeichnung: Integrin alpha 6B (ITGA6 Produkte)

Synonyme: CD49f antikoerper, ITGA6B antikoerper, VLA-6 antikoerper, 5033401O05Rik antikoerper, AI115430 antikoerper, Cd49f antikoerper, ITGA6 antikoerper, inta6 antikoerper, im:6897425 antikoerper, itga6 antikoerper, si:dkey-32o22.1 antikoerper, wu:fb80g02 antikoerper, LOC100221694 antikoerper, si:dkey-18j14.1 antikoerper, wu:fl20e08 antikoerper, zgc:113088 antikoerper, integrin subunit alpha 6 antikoerper, integrin alpha 6 antikoerper, integrin subunit alpha 6 L homeolog antikoerper, integrin, alpha 6a antikoerper, integrin, alpha 6b antikoerper, ITGA6 antikoerper, Itga6 antikoerper, itga6.L antikoerper, itga6a antikoerper, itga6b antikoerper

Hintergrund: Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. For integrin subunits alpha3 and alpha6, two cytoplasmic variants, A and B, have been identified.

Pathways: CXCR4-mediated Signaling Events, Brown Fat Cell Differentiation, Integrin Complex