Islet Amyloid Polypeptide (IAPP) Antikörper

Antigen: Islet Amyloid Polypeptide (IAPP)

Synonyme: DAP, IAP, AMYLIN, IAPP, Iapp, LOC100230121, Amylin

Klonalität: Polyklonal

Wirt: Huhn

Reaktivität: Human

Applikation: Western Blot (WB), ELISA

Produktnummer: ABIN334637

Produktbeschreibung

Immunogen: synthetic peptide based on human IAPP sequence:K-C-N-T-A-T-C-A-T-Q-R-L-A-N-F-L-V-H-S-S-N-N-F-G-A-I-L-S-S-T-N-V-G-S-N-T-Y

Format: Liquid

Beschreibung: Amylin, or Islet Amyloid Polypeptide (IAPP) P10997, is a 37-residue peptidehormone secreted by pancreatic beta-cells at the same time as insulin (in a roughly1:100 amylin:insulin ratio). Islet, or insulinoma, almyloid polypeptide (IAPP, oramylin) is commonly found in pancreatic islets of patients suffering diabetesmellitus type 2, or harboring an insulinoma. While the association of amylin with thedevelopment of type 2 diabetes has been known for some time, a direct causativerole for amylin has been harder to establish. Recent results suggest that amylin,like the related beta-amyloid (Abeta) associated with Alzherimer's disease, caninduce apoptotic cell-death in particular cultured cells, an effect that may berelevant to the deleopment of type 2 diabetes.

Spezifität: Predicted reactivity: cat, dog, mouse, rat.

Anwendungen

Applikationshinweise: Recommended Dilution 1:1000 (WB), 1:1000 (ELISA).

Buffer: Total IgY in PBS pH 8.0 + 0.02% sodium azide

Lagerung: store at 4°C, make aliquots to avoid working with a stock. Please, remember tospin tubes briefly prior to opening them to avoid any losses that might occur fromliquid material adhering to the cap or sides of the tubes.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-Islet Amyloid Polypeptide (IAPP) antibody