Neurotensin Receptor 2 (NTSR2) Antikörper

Antigen: Neurotensin Receptor 2 (NTSR2)

Synonyme: NT2R, NTRL, NTR2, NTSR2

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Western Blot (WB)

Produktnummer: ABIN317761

Produktbeschreibung

Produktmerkmale: Synonyms: NT-R-2, NTR2, NTSR2, Levocabastine-sensitive neurotensin receptor

Weitere Bezeichnung: Neurotensin receptor type 2

Swiss-Prot: O95665

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Beschreibung: Neurotensin (NT) initiates an intracellular response by interacting with the Gprotein-coupled receptors NTR1 (NTS1 receptor, high affinity NTR) and NTR2 (NTS2 receptor,levocabastine-sensitive neurotensin receptor), and the type I receptor NTR3 (NTS3receptor, sortilin-1, Gp95). NT has a wide distribution in regions of the brain and inperipheral tissues where NT receptors can contribute to hypotension, hyperglycemia,hypothermia, antinociception and regulation of intestinal motility and secretion. HL-60cells express NTR1, which can couple to Gq, Gi/o or Gs. Alternative splicing of rat NTR2 cangenerate a 5-transmembrane domain variant isoform that is coexpressed with the fulllength NTR2 throughout the brain and spinal cord. NTR3 activation in the murine microglialcell line N11 induces MIP-2, MCP-1, IL-1β and TNFα in an ERK1/2 and Akt kinase-dependentmanner.

Spezifität: NTR2 antibody detects endogenous levels of NTR2 protein. Species: Human, Mouse, Rat. Others not tested.

Anwendungen

Applikationshinweise: ELISA: 1: 40000~1: 60000. WB: 1: 500~1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Konzentration: 1,0 mg/ml

Reinigung: Aff - Purified

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Lagerung: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Beschränkungen: Nur für Forschungszwecke einsetzbar