Cholinergic Receptor, Muscarinic 1 (CHRM1) Antikörper

Antigen: Cholinergic Receptor, Muscarinic 1 (CHRM1)

Synonyme: M1, HM1, M1R, MGC30125, Chrm-1, mAChR, CHRM1, DKFZp459P0517

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Western Blot (WB)

Produktnummer: ABIN317696

Produktbeschreibung

Produktmerkmale: Synonyms: CHRM1, mAChR M1, mAChR-M1

Weitere Bezeichnung: Muscarinic acetylcholine receptor M1

Swiss-Prot: P11229

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Beschreibung: The muscarinic acetylcholine receptors (mAChR) mediate a variety of cellular responses,including inhibition of adenylate cyclase, breakdown of phosphoinositides andmodulation of potassium channels. The mAChRs transducer signals by coupling toG-proteins, which then modulate several downstream effector proteins and ion channels. Five mAChR subtypes have been identified, designated M1 to M5. The five receptorsubtypes show distinct patterns of tissue distribution, as well as distinct pharmacologicaland functional properties. The amino acid sequence of each mAChR subtype reflects a structure that is characteristicof G-protein coupled receptors, consisting of seven highly conserved transmembranesegments and a large intracellular region unique to each subtype, which constitutes theeffector-coupling domain.

Spezifität: MAChR M1 antibody detects endogenous levels of mAChR M1 protein. Species: Human. Others not tested.

Anwendungen

Applikationshinweise: ELISA: 1: 5000~1: 20000. WB: 1: 500~1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Konzentration: 1,0 mg/ml

Reinigung: Aff - Purified

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Lagerung: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Forschungsgebiet: Neurotransmitter , Hormone, Rezeptoren

Beschränkungen: Nur für Forschungszwecke einsetzbar