ARG2 Antikörper (C-Term)

Produktnummer ABIN311711

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-ARG2 Antikörper wird verwendet zum Nachweis von ARG2 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Schwein, Pferd, Kaninchen und Meerschweinchen. Er wurde validiert für WB.

Kurzübersicht für ARG2 Antikörper (C-Term) (ABIN311711)

Target: ARG2 (Arginase, Type II (ARG2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Schwein, Pferd, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARG2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ARG2 Antikörper

Bindungsspezifität: C-Term

Sequenz: SALDLVEVNP QLATSEEEAK TTANLAVDVI ASSFGQTREG GHIVYDQLPT

Kreuzreaktivität: Rind (Kuh), Hund, Human, Maus, Kaninchen, Ratte (Rattus)

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 87%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ARG2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ARG2

Anwendungsinformationen

Applikationshinweise: WB Suggested Anti-ARG2 Antibody Titration: 0.2-1 µg/mL
Positive Control: Jurkat cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 354 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ARG2 Antikörper (ABIN311711)

Lukasova, Malaval, Gille, Kero, Offermanns: "Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells." in: The Journal of clinical investigation, Vol. 121, Issue 3, pp. 1163-73, (2011) (PubMed).

Details zu ARG2

Target: ARG2 (Arginase, Type II (ARG2))

Andere Bezeichnung: Arginase-2

Hintergrund: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. ARG2 (type II isoform) is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood, it is thought to play a role in nitric oxide and polyamine metabolism.Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood, it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: -
Protein Interaction Partner: UBC, ARG1,
Protein Size: 354

Molekulargewicht: 39 kDa

Gen-ID: 384

NCBI Accession: NM_001172, NP_001163

UniProt: P78540