1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2) Antikörper

Antigen: 1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2)

Synonyme: BSCL, BSCL1, LPAAB, 1-AGPAT2, LPAAT-beta, AV000834, 2510002J07Rik, AGPAT2, MGC138073, zgc:153984

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN310613

Produktbeschreibung

Weitere Bezeichnung: AGPAT2

Beschreibung: AGPAT2 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in its gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance.This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Keywords: AGPAT2, NM_001012727, NP_001012745, Q5VUD3, NM_006412, NP_006403, O15120

Anwendungen

Applikationshinweise: ELISA titre: 1:312500 . Western Blotting: Suggested dilution at 5.0 ug/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as second antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2) antibody

Publikationen

Publikationen: Niesporek, Denkert, Weichert et al.: "Expression of lysophosphatidic acid acyltransferase beta (LPAAT-beta) in ovarian carcinoma: correlation with tumour grading and prognosis." in: British journal of cancer, Vol. 92, Issue 9, pp. 1729-36, 2005 (PubMed).